Millions of Americans from the Midwest to the Northeast to the South are facing the first deep freeze and snow of the season.

Parts of Indiana, Illinois, Wisconsin and Michigan saw more than 1 foot of lake effect snow on Monday, with the Indiana State Police saying it “responded to hundreds of calls for assistance.”

Flurries even fell in Nashville, Tennessee, and Myrtle Beach, South Carolina.

The snow moved east on Tuesday, hitting Buffalo and Syracuse in upstate New York, as well parts of Pennsylvania. Hydetown, Pennsylvania, recorded more than 12 inches of snow while Central Square, New York, near Syracuse, saw more than 11 inches.

New York City saw light snow on Tuesday, and local emergency officials warned of reduced visibility on Tuesday afternoon due to the combined gusty winds and snow showers.

The lake effect snow will continue across western New York and northern New England through Wednesday. A winter weather advisory is in effect in Buffalo for an additional 3 to 5 inches of snow through Wednesday morning.

Meanwhile, freezing temperatures are invading the Northeast and the South.

The cold blast brought record low temperatures to dozens of Southern cities, from Knoxville, Tennessee, to the Florida Keys.

Wednesday will be another chilly morning for the South. The wind chill — how cold it feels — will drop to 34 degrees in Jacksonville, Florida; 36 degrees in Charleston, South Carolina; 30 in Atlanta; 35 in Nashville, Tennessee, and Montgomery, Alabama; and 29 in Charlotte, North Carolina.

The Northeast will also be feeling the freeze, with temperatures feeling like the 20s to low 30s.